Description
Therapeutic action
– Antiprotozoal, antibacterial (group of nitroimidazoles)
Indications
– Amoebiasis, giardiasis, trichomoniasis
– Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp)
Presentation
– 500 mg tablet
Dosage and duration
– Amoebiasis
Child: 50 mg/kg once daily, without exceeding 2 g/day
Adult: 2 g once daily
The treatment lasts 3 days in intestinal amoebiasis; 5 days in hepatic amoebiasis.
–Giardiasis, trichomoniasis and bacterial vaginitis
Child: 50 mg/kg as a single dose, without exceeding 2 g
Adult: 2 g as a single dose
In the event of trichomoniasis, also treat sexual partner.
–Infections due to anaerobic bacteria
Child over 12 years and adult: initially 2 g then 1 g once daily or in 2 divided doses
According to indication, tinidazole may be used in combination with other antibacterials; treatment
duration depends on indication.
Contra-indications, adverse effects, precautions
– Do not administer to patients with allergy to tinidazole or another nitroimidazole (metronidazole,
secnidazole, etc.).
– May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness.
Risk of antabuse reaction when combined with alcohol.
– Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin
(increased plasma concentrations of these drugs).
–Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
–Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants);
Reviews
There are no reviews yet.