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Metronidazole( Flagyl) 400mg 5day dose

KSh 125.00

Antiprotozoal, antibacterial (group of nitroimidazoles) for Amoebiasis, giardiasis, trichomoniasis, Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp, etc.).

Do not take alcohol.

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SKU: Afya584634333806-1 Category:

Description

Therapeutic action

– Antiprotozoal, antibacterial (group of nitroimidazoles)

Indications

– Amoebiasis, giardiasis, trichomoniasis

– Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp, etc.)

Presentation

– 250 mg and 500 mg tablets

– 200 mg/5 ml oral suspension

Dosage and duration

Amoebiasis

Child: 45 mg/kg/day in 3 divided doses

Adult: 500 to 800 mg 3 times daily

The treatment lasts 5 days in intestinal amoebiasis and 5 to 10 days in hepatic amoebiasis.

giardiasis

Child: 30 mg/kg once daily for 3 days

Adult: 2 g once daily for 3 days

–Trichomoniasis and bacterial vaginitis

Adult: 2 g as a single dose

In the event of trichomoniasis, also treat sexual partner.

–Infections due to anaerobic bacteria

Child: 30 mg/kg/day in 3 divided doses

Adult: 500 mg 3 times daily

According to indication, metronidazole may be used in combination with other anti bacterials; treatment

duration depends on indication.

Contra-indications, adverse effects, precautions

– Do not administer to patients with hypersensitivity to metronidazole or another nitro imidazole

(tinidazole, secnidazole, etc.).

– May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine, headache, dizziness.

Risk of antabuse reaction when combined with alcohol.

– Administer with caution in patients taking oral anticoagulants (risk of haemorrhage), lithium, phenytoin,

ergometrine (increased plasma concentrations of these drugs).

– Reduce total daily dose to

⅓ and give once daily to patients with severe hepatic impairment.

–Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.

–Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed infants);

divide into smaller doses, avoid prolonged use.

Remarks

–Storage: below 25°C –

For the oral suspension: follow manufacturer’s instructions

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