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Co-Trimoxazole 960mg (Septrin) 100s tablets

KSh 385.00

SEPTRIN is used for the treatment of a variety of bacterial infections, including bronchitis and infections of the ear, sinus, kidney, bladder, stomach, bowel, skin and wounds.

Dose for Adults. Check Septin syrup for children

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SKU: Afya398874333703 Category: Tags: , ,

Description

Therapeutic action

– Combination of a sulfonamide with another antibacterial

Indications

– First-line treatment of pneumocystosis and isosporiasis

– Prophylaxis of pneumocystosis, toxoplasmosis and isosporiasis

– Brucellosis (when doxycycline is contra-indicated)

Presentation

– 400 mg SMX + 80 mg TMP and 800 mg SMX + 160 mg TMP tablets

– 100 mg SMX + 20 mg TMP tablet for paediatric use

– 200 mg SMX + 40 mg TMP/5 ml oral suspension

Dosage and duration

– Treatment of pneumocystosis

Child: 100 mg SMX + 20 mg TMP/kg/day in 2 divided doses

Adult: 4800 SMX + 960 TMP/day in 3 divided doses

Treatment of isosporiasis

Adult: 3200 mg SMX + 640 mg TMP/day in 2 divided doses

–Prophylaxis of pneumocystosis, toxoplasmosis and isosporiasis

Child: 50 mg SMX + 10 mg TMP/kg once daily, as long as necessary

Adult: 800 mg SMX + 160 mg TMP once daily, as long as necessary

–Brucellosis

Child: 40 mg SMX + 8 mg TMP/kg/day in 2 divided doses

Adult: 1600 mg SMX + 320 mg TMP/day in 2 divided doses

Duration

– Pneumocystosis: 14 to 21 days depending on severity; isosporiasis: 10 days; brucellosis: 6 weeks

Contra-indications, adverse effects, precautions

– Do not administer to children under 1 month.

– Do not administer to sulfonamide-allergic patients; patients with severe renal or hepatic impairment.

– May cause:

  • gastrointestinal disturbances, hepatic or renal disorders (crystalluria, etc.), metabolic disorders

(hyperkalaemia); neuropathy, photosensitivity, haemolytic anaemia in patients with G6PD deficiency;

  • allergic reactions (fever, rash, etc.) sometimes severe (Lyell’s and Stevens-Johnson syndromes,

haematological disorders, etc.). In these cases, stop treatment immediately;

  • megaloblastic anaemia due to folinic acid deficiency in patients receiving prolonged treatment (in this

event, administer calcium folinate).

– Adverse effects occur more frequently in patients with IV infection.

– In the event of prolonged treatment, monitor blood count if possible.

– Do not combine with methotrexate and phenytoin.

– Avoid combination with drugs inducing hyperkalaemia: potassium, spironolactone, enalapril, NSAIDs,

heparin (increased risk of hyperkalaemia).

– Monitor combination with zidovudine (increased haematotoxicity).

– Drink a lot of liquid during treatment.

–Pregnancy: no contra-indication. However, avoid using during the last month of pregnancy (risk of

–jaundice and haemolytic anaemia in the newborn infant).

Breast-feeding: avoid if premature infant, jaundice, low-birth weight, infant under one month of age. If cotrimoxazole is used, observe the infant for signs of jaundice.

Remarks

Storage: below 5°C Once the bottle has been opened, the oral suspension keep.

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