THERAPEUTIC ACTION– Third-generation cephalosporin antibacterial .INDICATIONS– Severe bacterial infections: meningitis, pneumonia, typhoid fever, leptospirosis, pyelonephritis, neurosyphilis, etc. – Cervicitis, urethritis and conjunctivitis due to Neisseria gonorrhoeae (in combination with a treatment for chlamydia, except in neonates), chancroid Presentation and route of administration– Powder for injection, in 250 mg or 1 g vials, to be dissolved • with water for injection for slow IV injection (3 minutes) or infusion (30 minutes) in 0,9% sodium chloride or 5% glucose DOSAGE – Severe bacterial infections Child 1 month and over: 50 to 100 mg/kg once daily in injection or infusion (max. 2 g/day) adult: 1 to 2 g once daily in injection or infusion (up to 4 g daily for typhoid fever) Duration varies according to indication and clinical response. – Gonococcal cervicitis and urethritis, chancroid Child under 45 kg: 125 mg IM as a single dose Child 45 kg and over and adult: 250 mg IM as a single dose – Gonococcal conjunctivitis neonate: 50 mg/kg IM as a single dose (max. 125 mg) adult: 1 g IM as a single dose for administration by IV route, ceftriaxone powder is to be reconstituted in water for injection only. for administration by IV infusion, dilute each dose of ceftriaxone in 5
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